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What is Prolotherapy, and How does it work?

Are you tired of living with persistent joint and muscle pain? Have you explored various treatment options without finding lasting relief? If so, you may be interested in learning about Prolotherapy injection, a unique approach to pain management that harnesses the body's natural healing abilities. In this comprehensive guide, we'll delve into what is Prolotherapy, how it works, its benefits, risks, and everything you need to know before considering this alternative treatment.

Book an Appointment with Dr.Collins For all Prolotherapy related concerns.

What is prolotherapy?

Prolotherapy: What It Is, How it works, Uses & Side Effects

Prolotherapy treatments, or regenerative injection or proliferation therapy, is a specialized treatment designed to alleviate joint and muscle pain. Unlike traditional pain management techniques that focus solely on symptom relief, Prolotherapy aims to address the underlying cause of pain by stimulating the body's natural healing process.

What is in prolotherapy injections?

Prolotherapy shots contain an irritant like dextrose solution. These injections often include natural substances like dextrose, saline, and sarapin, as well as a numbing agent like lidocaine and procaine. Unlike platelet-rich plasma injections, Prolotherapy doesn't need stem cells from the person getting treated. Dr.Collins is trained and certified in using medical-grade Ozone to enhance the effect of the above Prolotherapy formulas. This is known as ProlOzone and is proving to be even more effective than standard Prolotherapy.

How Does Prolotherapy Work?

The process of Prolotherapy involves injecting a solution containing a sugar or saline substance, along with Procaine and Lidocaine, directly into the affected joint or, muscle, or ligament. This solution acts as an irritant, prompting the body to initiate an inflammatory response. As a result, immune cells and other healing chemicals are mobilized to the area, stimulating the repair and regeneration of damaged soft tissue, including nerves, blood vessels, ligaments, tendons, and muscle tissue.

Benefits of Prolotherapy

Prolotherapy treatments offer a range of benefits for people suffering from chronic joint and muscle pain:

1. Reduces Pain and Stiffness: Prolotherapy injection effectively reduces pain and stiffness associated with conditions such as arthritis, tendinitis, and bursitis by promoting the formation of new collagen and strengthening ligaments, tendons, and joints.

2. Improves Joint Function: Enhanced ligaments and tendons provide better joint support, increasing stability and range of motion. This is beneficial for athletes and individuals with chronic pain that limits mobility.

3. Nonsurgical Treatment: Prolotherapy shots are a minimally invasive procedure that involves only injections, minimizing discomfort and reducing the risk of surgical complications. This makes it a great option for individuals seeking pain relief without surgery.

4. Cost-effective: Compared to ongoing medication or potential surgical costs, Prolotherapy can be a more cost-effective long-term solution for chronic pain. With fewer sessions than alternative treatments, it offers significant relief at a lower overall cost.

Does Prolotherapy work?

Studies have shown that Prolotherapy can provide long-lasting pain relief and improved function, sometimes lasting for several years with proper maintenance. This allows individuals to resume normal activities without constant pain.

Side Effects of Prolotherapy

Prolozone injections side effects include mild, temporary soreness or some swelling at the injection site, which resolves within a few days. Compared to other treatments, the side effects are minimal, making it a safe option for pain management.

Procedure Details: The prolotherapy procedure involves several steps:

Consultation: Patients undergo a thorough consultation with Dr. Collins to discuss their symptoms, medical history, and potential treatment options.

Preparation: Depending on the location of the treatment, patients may receive specific instructions regarding medications or activities to avoid before the injection.

Numbing: Local anesthetic is applied to minimize pain during the injection process, ensuring patient comfort throughout the procedure.

Injection: Thin needles deliver the prolotherapy solution directly into the affected joint or muscle, initiating the inflammatory response necessary for healing.

Number of Injections: The number of injections required varies depending on the type and severity of the condition. Multiple sessions may be advised to achieve optimal results.

Monitoring: Patients are monitored for progress, and additional treatments, such as physiotherapy, may be prescribed to enhance healing and improve outcomes.

Is Prolotherapy Right for You?

Prolotherapy is not a standard treatment approved by the FDA, and its effectiveness is still debated among experts. While some studies have shown promising results in reducing pain and improving function, others have found inconclusive evidence of its benefits. Discussing Prolotherapy with a healthcare provider is essential to determine if it's the right option for your condition. Dr.Collins has done thousands of injections of Prolotherapy with over 85% favorable results for many different sports or traumatic injuries.

What is the success rate of Prolotherapy?

The success of Prolotherapy varies based on factors like the patient's condition and response to treatment. Numerous studies suggest it can offer significant pain relief and enhance function for many individuals. Although opinions on its effectiveness may differ in the medical community, positive outcomes have been reported.


Prolotherapy injections offer a unique approach to pain management by harnessing the body's natural healing abilities. While it may not be suitable for everyone, it provides an alternative treatment option for people suffering from chronic joint and muscle pain. By contributing to repairing and regenerating damaged tissue, Prolotherapy can provide long-lasting relief and improve function, allowing individuals to resume normal activities without constant pain.

In summary,  Prolotherapy treatment represents a promising avenue for people seeking natural pain alleviation and improved quality of life. Call today (858) 333-5196 for a free 15 minute consultation with Dr. Collins, to determine if Prolotherapy is the right choice for your individual needs.

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About The Author: Dr. Collins

Author: Dr. Collins

Dr. Collins is a Pacific Northwest native and University of Oregon graduate in biology and comparative religions, practicing Naturopathic Medicine. Committed to harmonizing ancient traditions with modern science, he prioritizes holistic patient care in Oregon.


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